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      The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.

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          Abstract

          To fulfill the bioenergetic and biosynthetic demand of proliferation, T cells reprogram their metabolic pathways from fatty acid β-oxidation and pyruvate oxidation via the TCA cycle to the glycolytic, pentose-phosphate, and glutaminolytic pathways. Two of the top-ranked candidate transcription factors potentially responsible for the activation-induced T cell metabolic transcriptome, HIF1α and Myc, were induced upon T cell activation, but only the acute deletion of Myc markedly inhibited activation-induced glycolysis and glutaminolysis in T cells. Glutamine deprivation compromised activation-induced T cell growth and proliferation, and this was partially replaced by nucleotides and polyamines, implicating glutamine as an important source for biosynthetic precursors in active T cells. Metabolic tracer analysis revealed a Myc-dependent metabolic pathway linking glutaminolysis to the biosynthesis of polyamines. Therefore, a Myc-dependent global metabolic transcriptome drives metabolic reprogramming in activated, primary T lymphocytes. This may represent a general mechanism for metabolic reprogramming under patho-physiological conditions.

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          Author and article information

          Journal
          Immunity
          Immunity
          Elsevier BV
          1097-4180
          1074-7613
          Dec 23 2011
          : 35
          : 6
          Affiliations
          [1 ] Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
          Article
          S1074-7613(11)00515-2 NIHMS345587
          10.1016/j.immuni.2011.09.021
          3248798
          22195744
          ba44055a-a19f-4091-a849-06d332060393
          Copyright © 2011 Elsevier Inc. All rights reserved.
          History

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