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Health related quality of life in colorectal cancer patients: state of the art

  1 , 2 , 3 , 1 , 1 , 1 , 4 , 4 , , 4

BMC Surgery

BioMed Central

26th National Congress of the Italian Society of Geriatric Surgery

19-22 June 2013

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      Abstract

      Background

      Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females with a progressive increase in prevalence in industrialized countries. The loss of health due to the cancer and/or the consequence of the treatment may result in psychophysical, functional and social impairment; all of these affect health-related quality of life (QoL).

      Description

      The most frequently CRC-specific QoL questionnaires is the FACT-C. QoL is not only important for the well-being of cancer patient but it also influences survival and response to therapy. Many studies investigated various determinants involved in the assessment of QoL in CRC, suggesting that symptoms, surgical procedures and the number of comorbidity significantly affected QoL.

      Conclusion

      Despite that CRC patients have a relatively good QoL compared with the general population, a wide range of intervention could be undertaken to improve their QoL. The finding of this review may be useful for cancer clinicians in taking therapy and surveillance-related decisions. However, future research should be directed to large-scale prospective studies using well validated QoL instruments to facilitate comparison of results.

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      Most cited references 67

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      The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.

      A 36-item short-form (SF-36) was constructed to survey health status in the Medical Outcomes Study. The SF-36 was designed for use in clinical practice and research, health policy evaluations, and general population surveys. The SF-36 includes one multi-item scale that assesses eight health concepts: 1) limitations in physical activities because of health problems; 2) limitations in social activities because of physical or emotional problems; 3) limitations in usual role activities because of physical health problems; 4) bodily pain; 5) general mental health (psychological distress and well-being); 6) limitations in usual role activities because of emotional problems; 7) vitality (energy and fatigue); and 8) general health perceptions. The survey was constructed for self-administration by persons 14 years of age and older, and for administration by a trained interviewer in person or by telephone. The history of the development of the SF-36, the origin of specific items, and the logic underlying their selection are summarized. The content and features of the SF-36 are compared with the 20-item Medical Outcomes Study short-form.
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        A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity.

        Regression methods were used to select and score 12 items from the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) to reproduce the Physical Component Summary and Mental Component Summary scales in the general US population (n=2,333). The resulting 12-item short-form (SF-12) achieved multiple R squares of 0.911 and 0.918 in predictions of the SF-36 Physical Component Summary and SF-36 Mental Component Summary scores, respectively. Scoring algorithms from the general population used to score 12-item versions of the two components (Physical Components Summary and Mental Component Summary) achieved R squares of 0.905 with the SF-36 Physical Component Summary and 0.938 with SF-36 Mental Component Summary when cross-validated in the Medical Outcomes Study. Test-retest (2-week)correlations of 0.89 and 0.76 were observed for the 12-item Physical Component Summary and the 12-item Mental Component Summary, respectively, in the general US population (n=232). Twenty cross-sectional and longitudinal tests of empirical validity previously published for the 36-item short-form scales and summary measures were replicated for the 12-item Physical Component Summary and the 12-item Mental Component Summary, including comparisons between patient groups known to differ or to change in terms of the presence and seriousness of physical and mental conditions, acute symptoms, age and aging, self-reported 1-year changes in health, and recovery for depression. In 14 validity tests involving physical criteria, relative validity estimates for the 12-item Physical Component Summary ranged from 0.43 to 0.93 (median=0.67) in comparison with the best 36-item short-form scale. Relative validity estimates for the 12-item Mental Component Summary in 6 tests involving mental criteria ranged from 0.60 to 107 (median=0.97) in relation to the best 36-item short-form scale. Average scores for the 2 summary measures, and those for most scales in the 8-scale profile based on the 12-item short-form, closely mirrored those for the 36-item short-form, although standard errors were nearly always larger for the 12-item short-form.
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          Global cancer statistics

           A Jemal,  F Bray,  MM Center (2011)
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            Author and article information

            Affiliations
            [1 ]Department "G. F. Ingrassia" Section of Hygiene and Public Health, University of Catania, Catania, Italy
            [2 ]National School of Public Health, Carlos III Institute of Health, Madrid, Spain; REDISSEC, Spain
            [3 ]Department of Drug Sciences, Section of Biochemistry, University of Catania, Catania, Italy
            [4 ]Department of General Surgery, Section of General Surgery and Oncology, University Medical School of Catania, Italy
            Contributors
            Conference
            BMC Surg
            BMC Surg
            BMC Surgery
            BioMed Central
            1471-2482
            2013
            8 October 2013
            : 13
            : Suppl 2
            : S15
            24267735
            3851259
            1471-2482-13-S2-S15
            10.1186/1471-2482-13-S2-S15
            Copyright © 2013 Marventano et al; licensee BioMed Central Ltd.

            This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

            26th National Congress of the Italian Society of Geriatric Surgery
            Naples, Italy
            19-22 June 2013
            Categories
            Research Article

            Surgery

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