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      Colloid Osmotic Pressure Fluctuations and the Disequilibrium Syndrome during Hemodialysis

      , ,

      Nephron

      S. Karger AG

      Albumin, Mannitol, Disequilibrium syndrome, Colloid osmotic pressure, Osmolality

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          Abstract

          Changes in colloid osmotic pressure (COP), osmolality, blood urea nitrogen, glucose, electrolytes and arterial blood gases were correlated with the symptoms that occurred during 46 dialyses in 10 stable, chronic hemodialysis patients who had symptoms attributable to the disequilibrium syndrome. The onset and severity of symptoms were consistently related to fluctuations in COP. Saline administration failed to relieve them, whereas the continuous infusion of salt-poor human serum albumin (1 g/kg) or mannitol (1 g/kg) successfully controlled the COP fluctuations and most of the symptomatology. The relationship of the COP fluctuations to existing theories on the pathogenesis of the disequilibrium syndrome were discussed.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1974
          1974
          28 November 2008
          : 13
          : 3
          : 245-252
          Affiliations
          Department of Surgery of the State University of New York at Buffalo and the Buffalo General Hospital, Buffalo, N. Y.
          Article
          180399 Nephron 1974;13:245–252
          10.1159/000180399
          4422817
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
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