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      Changing Trends in Stomach Cancer Throughout the World

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          Abstract

          Purpose of Review

          The paper aims to discuss the global trends in gastric cancer incidence in relation to important factors involved in the pathogenesis of gastric cancer.

          Recent Findings

          Despite a significant worldwide decline, gastric cancer remains a common cause of cancer death. The decline has been multifactorial and preceded the fall in Helicobacter pylori prevalence. The initial decline was associated with changes in food preservation and availability, especially of fresh fruits and vegetables, followed by a decline in the primary etiologic factor, H. pylori. Gastric cancer incidence remains high in East Asia, intermediate in Latin America, and low in developed countries. Significant racial/ethnic variability exists.

          Summary

          The rapid decline in incidence in East Asia will continue as primary and secondary prevention strategies are implemented. The incidence in Latin America is unlikely to decline significantly over the next few decades given high H. pylori prevalence in the young. Ultimately, global H. pylori eradication will be needed to largely eliminate gastric cancer.

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          Author and article information

          Journal
          100888896
          21830
          Curr Gastroenterol Rep
          Curr Gastroenterol Rep
          Current gastroenterology reports
          1522-8037
          1534-312X
          1 December 2019
          August 2017
          18 December 2019
          : 19
          : 8
          : 36
          Affiliations
          [1 ]Department of Medicine, Baylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, TX, USA
          [2 ]Michael E. DeBakey Veterans Affairs Medical Center, RM 3A-318B (111D), 2002 Holcombe Boulevard, Houston, TX 77030, USA
          Author notes
          David Y. Graham: dgraham@ 123456bcm.edu
          Article
          PMC6918953 PMC6918953 6918953 nihpa1061574
          10.1007/s11894-017-0575-8
          6918953
          28730504
          ba7f14d4-9f5c-49bb-bc60-f4e359fdd649
          Categories
          Article

          Natural history,Epidemiology,Risk factors, Helicobacter pylori ,Disparities,Gastric cancer

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