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      Uroporphyria: Some Notes on Its Ancient Historical Background

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          Abstract

          Black urine is recorded in all ancient urology as a negative prognostic sign, often linked with the presence of blood; its presence can also be considered as a sign of massive hemolytic crisis, especially if associated with specific nosological patterns. The Hippocratic case of Epidemics III, 11 has recently been diagnosed as an intermittent acute porphyria. Despite the difficult ‘retrospective’ diagnosis of an ancient case, it seems likely that the Hippocratic physicians empirically knew clinical associations of symptoms that modern medicine could consider as the first descriptions of porphyria.

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          Most cited references 2

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          Was hippocrates the first to describe a case of acute porphyria?

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            Thirty years with biochemistry and clinic of porphyrias in man and animals

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              Author and article information

              Journal
              AJN
              Am J Nephrol
              10.1159/issn.0250-8095
              American Journal of Nephrology
              S. Karger AG
              978-3-8055-6855-5
              978-3-318-00128-0
              0250-8095
              1421-9670
              1999
              April 1999
              23 April 1999
              : 19
              : 2
              : 159-162
              Affiliations
              Section of History of Medicine, Department of Experimental Medicine and Pathology, University of Rome ‘La Sapienza’, Rome, Italy
              Article
              13443 Am J Nephrol 1999;19:159–162
              10.1159/000013443
              10213811
              © 1999 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              References: 28, Pages: 4
              Product
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/13443
              Categories
              Origins of Nephrology – Antiquity

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