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Overview and Findings from the Rush Memory and Aging Project
David A. Bennett ,
Julie A. Schneider ,
Aron S. Buchman ,
Lisa L. Barnes ,
Patricia A. Boyle ,
Robert S. Wilson
June 01 2012
June 01 2012
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Abstract
The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic
cohort study of common chronic conditions of aging with an emphasis on decline in
cognitive and motor function and risk of Alzheimer's disease (AD). In this manuscript,
we first summarize the study design and methods. Then, we present data on: (1) the
relation of motor function to cognition, disability, and death; (2) the relation of
risk factors to cognitive and motor outcomes, disability and death; (3) the relation
of neuropathologic indices to cognitive outcomes; (4) the relation of risk factors
to neuropathologic indices; and (5) additional study findings. The findings are discussed
and contextualized.