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      Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

      , , , , , ,

      Cell

      Elsevier BV

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          Abstract

          Growth factors can promote cell survival by activating the phosphatidylinositide-3'-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood. We show that growth factor activation of the PI3'K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival. Akt phosphorylates BAD in vitro and in vivo, and blocks the BAD-induced death of primary neurons in a site-specific manner. These findings define a mechanism by which growth factors directly inactivate a critical component of the cell-intrinsic death machinery.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          October 1997
          October 1997
          : 91
          : 2
          : 231-241
          Article
          10.1016/S0092-8674(00)80405-5
          9346240
          © 1997

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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