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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Jun Wu ,
Pontus Boström ,
Lauren M. Sparks ,
Li Ye ,
Jang Hyun Choi ,
An-Hoa Giang ,
Melin Khandekar ,
Kirsi A. Virtanen ,
Pirjo Nuutila ,
Gert Schaart ,
Kexin Huang ,
Hua Tu ,
Wouter D. van Marken Lichtenbelt ,
Joris Hoeks ,
Sven Enerbäck ,
Patrick Schrauwen ,
Bruce M. Spiegelman
July 2012
July 2012
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Abstract
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending
against hypothermia and obesity. Recent data suggest that there are two distinct types
of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive
cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation
of "beige" cells from murine white fat depots. Beige cells resemble white fat cells
in having extremely low basal expression of UCP1, but, like classical brown fat, they
respond to cyclic AMP stimulation with high UCP1 expression and respiration rates.
Beige cells have a gene expression pattern distinct from either white or brown fat
and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide
evidence that previously identified brown fat deposits in adult humans are composed
of beige adipocytes. These data provide a foundation for studying this mammalian cell
type with therapeutic potential. PAPERCLIP:
Copyright © 2012 Elsevier Inc. All rights reserved.