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      Control strategies on mosquitos population for the fight against arboviruses

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          Abstract

          In the fight against vector-borne arboviruses, an important strategy of control of epidemic consists in controlling the population of vector, \textit{Aedes} mosquitoes in this case. Among possible actions, two techniques consist in releasing mosquitoes to reduce the size of the population (Sterile Insect Technique) or in replacing the wild population by a population carrying a bacteria, called \textit{Wolbachia}, blocking the transmission of viruses from mosquitoes to human. This paper is concerned with the question of optimizing the release protocol for these two strategies with the aim of getting as close as possible to the objectives. Starting from a mathematical model describing the dynamics of the population, we include the control function and introduce the cost functional for both \textit{population replacement} and \textit{Sterile Insect Technique} problems. Next, we establish some properties of the optimal control and illustrate them with some numerical simulations.

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          Wolbachia: master manipulators of invertebrate biology.

          Wolbachia are common intracellular bacteria that are found in arthropods and nematodes. These alphaproteobacteria endosymbionts are transmitted vertically through host eggs and alter host biology in diverse ways, including the induction of reproductive manipulations, such as feminization, parthenogenesis, male killing and sperm-egg incompatibility. They can also move horizontally across species boundaries, resulting in a widespread and global distribution in diverse invertebrate hosts. Here, we review the basic biology of Wolbachia, with emphasis on recent advances in our understanding of these fascinating endosymbionts.
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            Wolbachia and cytoplasmic incompatibility in mosquitoes.

            Wolbachia are maternally inherited bacteria that induce cytoplasmic incompatibility in mosquitoes, and are able to use these patterns of sterility to spread themselves through populations. For this reason they have been proposed as a gene drive system for mosquito genetic replacement, as well as for the reduction of population size or for modulating population age structure in order to reduce disease transmission. Here, recent progress in the study of mosquito Wolbachia is reviewed. We now have much more comprehensive estimates of the parameters that can affect the spread of Wolbachia through natural populations from low starting frequencies, and for waves of spread to be maintained in the face of partial barriers to gene flow. In Aedes albopictus these dynamics are extremely favourable, with very high maternal transmission fidelity and levels of incompatibility recorded. Correspondence between measurements taken in the lab and field is much better than in the Drosophila simulans model system. Important research goals are also discussed, including Wolbachia transformation, interspecific transfer and the elucidation of the mechanisms of incompatibility and rescue; all will be aided by a wealth of new Wolbachia genome information.
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              Wolbachia-based technologies for insect pest population control.

              Wolbachia are a group of obligatory intracellular and maternally inherited bacteria found in many arthropod species, including insects, mites, spiders, springtails, crustaceans, as well as in certain nematodes. Several PCR-based surveys suggest that over 20% of the arthropod species may be Wolbachia-infected, rendering this bacterium the most ubiquitous intracellular symbiont yet described. Wolbachia have recently attracted attention for their potential as novel and environmentally friendly bio-control agents. Wolbachia are able to invade and maintain themselves in the arthropod species through manipulation of the host's reproduction. Several strategies can be distinguished, one of which is cytoplasmic incompatibility (CI). Wolbachia-induced cytoplasmic incompatibility can be used beneficially in the following ways: (a) as a tool for insect pest population control in a way analogous to the "Sterile Insect technique" (SIT) and (b) as a drive system to spread desirable genotypes in field arthropod populations. In addition, virulent Wolbachia strains offer the potential to control vector species by modifying their population age structure. In the present chapter, I summarize the recent developments in Wolbachia research with an emphasis on the applied biology of Wolbachia and conclude with the challenges that Wolbachia researchers will face if they want to use and/or introduce Wolbachia into pest and vector species ofeconomic, environmental and public health relevance and, through Wolbachia-based technologies, to suppress or modify natural populations.
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                Author and article information

                Journal
                17 January 2019
                Article
                1901.05688
                bab7b538-e49a-4fa3-8eb0-a5fe07a9572b

                http://arxiv.org/licenses/nonexclusive-distrib/1.0/

                History
                Custom metadata
                math.AP math.OC
                ccsd

                Analysis,Numerical methods
                Analysis, Numerical methods

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