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      Collagen from Marine Biological Sources and Medical Applications

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          Most cited references 106

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          The collagen family.

          Collagens are the most abundant proteins in mammals. The collagen family comprises 28 members that contain at least one triple-helical domain. Collagens are deposited in the extracellular matrix where most of them form supramolecular assemblies. Four collagens are type II membrane proteins that also exist in a soluble form released from the cell surface by shedding. Collagens play structural roles and contribute to mechanical properties, organization, and shape of tissues. They interact with cells via several receptor families and regulate their proliferation, migration, and differentiation. Some collagens have a restricted tissue distribution and hence specific biological functions.
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            Is Open Access

            Drug delivery systems: An updated review

            Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery particularly for peptide and protein therapeutics. For this purpose, several drug delivery systems have been formulated and are being investigated for nasal and pulmonary delivery. These include liposomes, proliposomes, microspheres, gels, prodrugs, cyclodextrins, among others. Nanoparticles composed of biodegradable polymers show assurance in fulfilling the stringent requirements placed on these delivery systems, such as ability to be transferred into an aerosol, stability against forces generated during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a predetermined manner, and degradation within an acceptable period of time.
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              Collagens at a glance.

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                Author and article information

                Affiliations
                [1 ]The Engineering Research Center of Peptide Drug Discovery and Development; China Pharmaceutical University; Nanjing 211198 Jiangsu Province P. R. China
                [2 ]Department of Marine Pharmacy; College of Life Science and Technology; P. R. China Pharmaceutical University; Nanjing 211198 Jiangsu Province P. R. China
                Journal
                Chemistry & Biodiversity
                Chem. Biodiversity
                Wiley
                16121872
                May 2018
                May 2018
                May 21 2018
                : 15
                : 5
                : e1700557
                10.1002/cbdv.201700557
                © 2018

                http://doi.wiley.com/10.1002/tdm_license_1.1

                http://onlinelibrary.wiley.com/termsAndConditions#vor

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