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      Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomised trial

      , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
      The Lancet HIV
      Elsevier BV
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          Abstract

          Universal antiretroviral therapy (ART), as per the 2015 WHO recommendations, might reduce population HIV incidence. We investigated the effect of universal test and treat on HIV acquisition at population level in a high prevalence rural region of South Africa.

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          Most cited references28

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          Antiretroviral Therapy for the Prevention of HIV-1 Transmission.

          An interim analysis of data from the HIV Prevention Trials Network (HPTN) 052 trial showed that antiretroviral therapy (ART) prevented more than 96% of genetically linked infections caused by human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. ART was then offered to all patients with HIV-1 infection (index participants). The study included more than 5 years of follow-up to assess the durability of such therapy for the prevention of HIV-1 transmission.
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            Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection

            New England Journal of Medicine, 373(9), 795-807
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              • Record: found
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              • Article: not found

              A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.

              In sub-Saharan Africa, the burden of human immunodeficiency virus (HIV)-associated tuberculosis is high. We conducted a trial with a 2-by-2 factorial design to assess the benefits of early antiretroviral therapy (ART), 6-month isoniazid preventive therapy (IPT), or both among HIV-infected adults with high CD4+ cell counts in Ivory Coast.
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                Author and article information

                Journal
                The Lancet HIV
                The Lancet HIV
                Elsevier BV
                23523018
                March 2018
                March 2018
                : 5
                : 3
                : e116-e125
                Article
                10.1016/S2352-3018(17)30205-9
                29199100
                bad43679-0150-4cb1-a6a4-d304070a4185
                © 2018

                https://www.elsevier.com/tdm/userlicense/1.0/

                http://www.elsevier.com/open-access/userlicense/1.0/

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