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      Missing pieces in the NF-kappaB puzzle.

      Cell

      Active Transport, Cell Nucleus, Animals, Catalytic Domain, Cell Nucleus, metabolism, Cytoplasm, Enzyme Activation, Gene Expression Regulation, Humans, I-kappa B Kinase, NF-kappa B, Protein-Serine-Threonine Kinases, Signal Transduction

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          Abstract

          The regulation of the transcription factor NF-kappaB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-kappaB regulation is the IkappaB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.

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          11983155

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