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      Hepatitis C virus subtype 3a was introduced in the USSR in the early 1980s.

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          Abstract

          A total of 2120 nucleotide sequences of the NS5b region of HCV subtype 3a were analysed, including 310 strains derived from former republics of the USSR (Azerbaijan, Estonia, Lithuania, Russia, Tajikistan and Uzbekistan). Among the viral isolates collected from former regions of the Soviet Union, 294 strains formed 3 sustained phylogenetic clusters, with each having a common origin. Phylodynamic analysis demonstrated that the most recent common ancestors of the current strains inside the three clusters were introduced into the USSR population in 1981±1, 1984±2 and 1985±2, respectively (the confidence intervals were calculated using Student's t-distribution, P<0.05). The time estimation obtained for HCV subtype 3a correlated well with the historical and epidemiological context of this period, and in particular with the start of widespread injection drug use in the USSR in the first half of the 1980s.

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          Author and article information

          Journal
          J Gen Virol
          The Journal of general virology
          Microbiology Society
          1465-2099
          0022-1317
          Aug 2017
          : 98
          : 8
          Affiliations
          [1 ] Translational Biomedicine Laboratory, Gamaleya Research Center of Epidemiology and Microbiology, Moscow 123098, Russia.
          [2 ] Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow 119991, Russia.
          [3 ] Department of Molecular Virology of Flaviviruses and Viral Hepatitis, State Research Center of Virology and Biotechnology 'Vector', Koltsovo, Novosibirsk Region 630559, Russia.
          [4 ] Department of Viral Hepatitis, Research Center, Russian Medical Academy of Postgraduate Education, Moscow 125284, Russia.
          [5 ] Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
          [6 ] Laboratory of Bionanotechnology, Microbiology and Virology, Novosibirsk State University, Novosibirsk 630090, Russia.
          Article
          10.1099/jgv.0.000878
          28742003
          badc2943-0859-4076-9a03-9fbcd3260a37
          History

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