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      Identification of Heregulin, a Specific Activator of p185erbB2

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          Ligand: a versatile computerized approach for characterization of ligand-binding systems.

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            Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

            A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning. Its primary sequence is very similar to that of the human epidermal growth factor receptor and the v-erbB oncogene product; the chromosomal location of the gene for this protein is coincident with the neu oncogene, which suggests that the two genes may be identical.
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              Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

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                Author and article information

                Journal
                Science
                Science
                American Association for the Advancement of Science (AAAS)
                0036-8075
                1095-9203
                May 22 1992
                May 22 1992
                : 256
                : 5060
                : 1205-1210
                Article
                10.1126/science.256.5060.1205
                badcb045-a66c-4080-b1e9-de65e9ab6219
                © 1992

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