Effective waste management is an important aspect of green building development. However, a number of studies find that construction waste minimization actions are not satisfactorily performed in practice. Thus, it is of significance to identify the driving factors that influence construction practitioners' waste minimization behavior. This paper aims to explore the driving factors by comparing the affecting factors and construction waste minimization behavior between Hong Kong and Shenzhen. Firstly, through a comprehensive literature review, potential affecting factors were categorized into five groups: background information variables, construction waste minimization intentions, economic viability, governmental supervision, and project constraints. Based on the identified factors, a questionnaire was initially designed and then refined through a focus group meeting with three experienced experts. A total of 166 questionnaires were collected and non-parametric tests (Mann-Whitney U Test and Kruskal-Wallis Test) were conducted to investigate the underlying driving factors. Results revealed that background information variables play insignificant roles in construction waste minimization. Compared with other affecting factors (i.e., waste minimization intentions, governmental supervision, project constraints), economic viability is the most important driving factor that determines construction waste minimization. Results suggested that local governments should make policies that increase practitioners' profit, rather than just increasing their intentions or regulating waste management behavior.