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      Effect of Vitamin D 3 Treatment in the Neonatal or Adolescent Age (Hormonal Imprinting) on the Thymic Glucocorticoid Receptor of the Adult Male Rat

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          Single neonatal treatment with 25 μg vitamin D<sub>3</sub> significantly decreased the thymic glucocorticoid receptor density (B<sub>max</sub>) of 6-week-old male rats. In females, a similar treatment did not cause any changes. Single vitamin D<sub>3</sub> treatment (50 μg) during adolescence (i.e. 6-week-old animals) significantly increased the glucocorticoid receptor density in adult (10-week-old) males. No significant changes in receptor affinity (K<sub>d</sub>) could be observed. Considering that in earlier experiments similar neonatal treatments influenced bone mineral mass and sexual behavior, the hormonal imprinting effect of vitamin D<sub>3</sub> and its harmful effect on the development of other members of the steroid receptor superfamily, seems to be unquestionable.

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          Analysis of radioligand binding experiments

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            Induction of microsomal cytochrome P-450 enzymes: The first Bernard B. Brodie lecture at Pennsylvania State University

             Allan Conney (1986)

              Author and article information

              Horm Res Paediatr
              Hormone Research in Paediatrics
              S. Karger AG
              December 1999
              10 January 2000
              : 51
              : 6
              : 280-283
              Department of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary
              23415 Horm Res 1999;51:280–283
              © 2000 S. Karger AG, Basel

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              Page count
              Figures: 2, Tables: 1, References: 21, Pages: 4
              Original Paper


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