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      Effect of Vitamin D 3 Treatment in the Neonatal or Adolescent Age (Hormonal Imprinting) on the Thymic Glucocorticoid Receptor of the Adult Male Rat

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          Abstract

          Single neonatal treatment with 25 μg vitamin D<sub>3</sub> significantly decreased the thymic glucocorticoid receptor density (B<sub>max</sub>) of 6-week-old male rats. In females, a similar treatment did not cause any changes. Single vitamin D<sub>3</sub> treatment (50 μg) during adolescence (i.e. 6-week-old animals) significantly increased the glucocorticoid receptor density in adult (10-week-old) males. No significant changes in receptor affinity (K<sub>d</sub>) could be observed. Considering that in earlier experiments similar neonatal treatments influenced bone mineral mass and sexual behavior, the hormonal imprinting effect of vitamin D<sub>3</sub> and its harmful effect on the development of other members of the steroid receptor superfamily, seems to be unquestionable.

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          Most cited references 2

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          Analysis of radioligand binding experiments

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            Induction of microsomal cytochrome P-450 enzymes: The first Bernard B. Brodie lecture at Pennsylvania State University

             Allan Conney (1986)
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              Author and article information

              Journal
              HRE
              Horm Res Paediatr
              10.1159/issn.1663-2818
              Hormone Research in Paediatrics
              S. Karger AG
              1663-2818
              1663-2826
              1999
              December 1999
              10 January 2000
              : 51
              : 6
              : 280-283
              Affiliations
              Department of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary
              Article
              23415 Horm Res 1999;51:280–283
              10.1159/000023415
              10640889
              © 2000 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 2, Tables: 1, References: 21, Pages: 4
              Categories
              Original Paper

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