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      Selenium and Haemodialysis: Serum Selenium Levels in Healthy Persons, Non-Cancer and Cancer Patients with Chronic Renal Failure

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          Abstract

          In 40 healthy persons, 11 nondialyzed uremic patients and 27 dialyzed uremic patients, of whom 4 also had cancer, the selenium concentration in serum was determined. The mean serum selenium concentration in healthy persons was 13.6 ± 0.8 μg/dl, in nondialyzed patients 11.9 ± 1.9 μg/dl and in dialyzed uremic patients 11.3 ± 1.0 μg/dl. There was a significant statistical difference between healthy persons and uremic patients (p < 0.00l), but not between dialyzed and nondialyzed uremic patients. The subgroup of cancer patients on hemodialysis also had low serum selenium concentrations. The possible role of low selenium levels as one of the factors responsible for the increased incidence of malignancy in patients with chronic renal failure is supported by several facts such as: (a) low serum selenium levels detected in patients with malignant diseases; (b) the higher cancer incidence in inhabitants of low-selenium areas, and (c) the known ability of selenium to inhibit many types of experimental carcinogenesis.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          04 December 2008
          : 41
          : 3
          : 217-222
          Affiliations
          Departments of Experimental Physiology and Biological Chemistry, University of Ioannina, Greece; Renal Unit of ‘Agia Sofia’ General Hospital, University of Thessaloniki, Greece
          Article
          183586 Nephron 1985;41:217–222
          10.1159/000183586
          4058621
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Selenium, Uremia, Haemodialysis, Carcinogenesis, Trace elements

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