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Single Dose Toxicity of Chukyu (spine-healing) Pharmacopuncture Injection in the Muscle of Rats

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      Abstract

      Objectives:This study was performed to analyze the single dose toxicity of Chukyu (spine-healing) pharmacopuncture.Methods:All experiments were conducted at the Biotoxtech, an institution authorized to perform non-clinical studies under the regulations of Good Laboratory Practice (GLP) regulations. Sprague-Dawley rats were chosen for the pilot study. Doses of Chukyu (spine-healing) pharmacopuncture, 0.1, 0.5 and 1.0 mL, were administered to the experimental groups, and a dose of normal saline solution, 1.0 mL, was administered to the control group. This study was conducted under the approval of the Institutional Animal Ethic Committee.Results:No deaths or abnormalities occurred in any of the four groups. No significant changes in weight, hematological parameters or clinical chemistry between the control group and the experimental groups were observed. To check for abnormalities in organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues except in one case, where interstitial infiltrating macrophages were found in one female rat in the 0.5-mL/animal experimental group.Conclusion:The above findings suggest that treatment with Chukyu (spine-healing) pharmacopuncture is relatively safe. Further studies on this subject are needed to yield more concrete evidence.

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            Author and article information

            Affiliations
            [1 ] Department of Acupuncture & Moxibustion Medicine, Wonkwang University Gwangju Korean Medical Hospital, Gwangju, Korea
            [2 ] ALS Center of Wonkwang University Gwangju Korean Medical Hospital, Gwangju, Korea
            [3 ] Department of Neuropsychiatry, Hospital of Korean Medicine, Kyung Hee University Medical center, Seoul, Korea
            [4 ] Department of Acupuncture & Moxibustion Medicine, Semyung University Korean Medical Hospital, Chungju, Korea
            [5 ] Department of Acupuncture & Moxibustion Medicine, Dongguk University College of Korean Medicine, Gyeongju, Korea
            [6 ] Department of Meridian & Acupoint, Wonkwang University College of Korean Medicine, Iksan, Korea
            Author notes
            * Corresponding Author Sungchul Kim. Wonkwang Gwangju Oriental Medical Hospital, 543-8 Juweol 1-dong, Nam-gu, Gwangju 503-310, Korea. Tel: +82-62-670-6441 Fax: +82-62-670-6767 E-mail: kscndl@ 123456hanmail.net
            Journal
            J Pharmacopuncture
            J Pharmacopuncture
            J Pharmacopunct
            Journal of Pharmacopuncture
            KOREAN PHARMACOPUNCTURE INSTITUTE
            2093-6966
            2234-6856
            March 2014
            : 17
            : 1
            : 35-43
            4331982
            10.3831/KPI.2014.17.005
            Copyright ©2014, KOREAN PHARMACOPUNCTURE INSTITUTE

            This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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