Comparison of the heritability of schizophrenia and endophenotypes in the COGS-1 family study.

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Abstract

Twin and multiplex family studies have established significant heritability for schizophrenia (SZ), often summarized as 81%. The Consortium on the Genetics of Schizophrenia (COGS-1) family study was designed to deconstruct the genetic architecture of SZ using neurocognitive and neurophysiological endophenotypes, for which heritability estimates ranged from 18% to 50% (mean = 30%). This study assessed the heritability of SZ in these families to determine whether there is a "heritability gap" between the diagnosis and related endophenotypes.

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Journal

Journal ID (iso-abbrev): Schizophr Bull

Title: Schizophrenia bulletin

ISSN (Electronic): 1745-1701

ISSN (Print): 0586-7614

Publication date (Electronic): Nov 2014

Volume: 40

Issue: 6

Affiliations

[1 ] Department of Psychiatry, University of California San Diego, La Jolla, CA; VISN-22 Mental Illness, Research, Education and Clinical Center, San Diego Healthcare System La Jolla, CA; glight@ucsd.edu.

[2 ] Department of Psychiatry, University of California San Diego, La Jolla, CA;

[3 ] Department of Psychiatry, University of Pennsylvania, Philadelphia, PA;

[4 ] Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO;

[5 ] Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA; VA Greater Los Angeles Healthcare System, Los Angeles, CA;

[6 ] Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA;

[7 ] Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA;

[8 ] Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA; VA Puget Sound Health Care System, Seattle, WA;

[9 ] Department of Psychiatry, Harvard Medical School, Boston, MA; Massachusetts Mental Health Center Public Psychiatry, Division of the Beth Israel Deaconess Medical Center, Boston, MA;

[10 ] Department of Psychiatry, Mount Sinai School of Medicine, New York, NY; James J. Peters VA Medical Center, New York, NY;

[11 ] Department of Biostatistics, University of California, Los Angeles School of Public Health, Los Angeles, CA;

[12 ] Department of Psychiatry, University of California San Diego, La Jolla, CA; Center for Behavioral Genomics, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA; Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA.

Article

Publisher Item ID: sbu064

DOI: 10.1093/schbul/sbu064

PMC ID: 4193725

PubMed ID: 24903414

SO-VID: bb4b5895-bf6a-4f6f-b933-4c98422ebe4b

History

Keywords: biomarkers,cognition,endophenotypes,heritability,psychosis,schizophrenia

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Keywords: biomarkers, cognition, endophenotypes, heritability, psychosis, schizophrenia

Comparison of the heritability of schizophrenia and endophenotypes in the COGS-1 family study.

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