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      N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma.

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          Abstract

          Loss of intercellular adhesion and increased cell motility promote tumor cell invasion. In the present study, E- and N-cadherin, members of the classical cadherin family, are investigated as inducers of epithelial-to-mesenchymal transition (EMT) that is thought to play a fundamental role during the early steps of invasion and metastasis of carcinomas. Cell growth factors are known to regulate cell adhesion molecules. The purpose of the study presented here was to investigate whether a gain in N-cadherin in pancreatic cancer is involved in the process of metastasis via EMT and whether its expression is affected by growth factors.

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          Author and article information

          Journal
          Clin Cancer Res
          Clinical cancer research : an official journal of the American Association for Cancer Research
          American Association for Cancer Research (AACR)
          1078-0432
          1078-0432
          Jun 15 2004
          : 10
          : 12 Pt 1
          Affiliations
          [1 ] Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan. sana@kuhp.kyoto-u.ac.jp
          Article
          10/12/4125
          10.1158/1078-0432.CCR-0578-03
          15217949
          bb4d0459-35e0-4f75-a011-047a3795214d
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