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      Study of Testicular Feedback in Male Rats Using Artificial Cryptorchidism as a Model

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      Hormone Research in Paediatrics

      S. Karger AG

      Cryptorchid, Testosterone, Inhibin

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          Plasma LH, FSH and testosterone were measured in testosterone-treated and untreated cryptorchid and castrated male rats. Exogenous testosterone prevented the increase in basal LH but not FSH levels seen in the untreated cryptorchids. Increases in plasma LH and FSH in response to LH-RH were greater in the cryptorchid as compared to the control group and this could not be reversed by exogenous testosterone, suggesting that spermatogenesis-related feedback factors regulate LH as well as FSH at the pituitary level in the intact rat. The results were consistent with a reduced but nevertheless significant secretion of inhibin by the cryptorchid testis. Basal plasma testosterone levels and ventral prostate weights were not significantly different from intact animals.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 10
          : 6
          : 310-319
          Department of Obstetrics and Gynaecology, University of Marburg, Marburg, and Department of Urology, City Hospital, Solingen
          179013 Horm Res 1979;10:310–319
          © 1979 S. Karger AG, Basel

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          Pages: 10


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