Zinc finger protein 804A (ZNF804A) and verbal deficits in individuals with autism.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

In a genome-wide association study of autism, zinc finger protein 804A (ZNF804A) single nucleotide polymorphisms (SNPs) were found to be nominally associated in verbally deficient individuals with autism. Zinc finger protein 804A copy number variations (CNVs) have also been observed in individuals with autism. In addition, ZNF804A is known to be involved in theory of mind (ToM) tasks, and ToM deficits are deemed responsible for the communication and social challenges faced by individuals with autism. We hypothesized that ZNF804A could be a risk gene for autism.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): J Psychiatry Neurosci

Title: Journal of psychiatry & neuroscience : JPN

ISSN (Electronic): 1488-2434

ISSN (Print): 1180-4882

Publication date (Electronic): Sep 2014

Volume: 39

Issue: 5

Affiliations

[1 ] Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan.

[2 ] Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.

[3 ] Department of Psychiatry, Hirosaki University School of Medicine, Hirosaki, Japan.

[4 ] Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan.

[5 ] Department of Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan.

[6 ] Department of Child and Adolescent Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.

[7 ] Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan; Faculty of Sociology, Chukyo University, Toyota, Japan.

[8 ] Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Article

Publisher Item ID: 10.1503/jpn.130126

PMC ID: 4160358

PubMed ID: 24866414

SO-VID: bb5c646f-32e8-4db9-a3c6-2c6bf3ffcadc

History

Data availability:

Comments

Comment on this article

Cited by 9

See all cited by