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      Bacterial quorum sensing: its role in virulence and possibilities for its control.

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          Abstract

          Quorum sensing is a process of cell-cell communication that allows bacteria to share information about cell density and adjust gene expression accordingly. This process enables bacteria to express energetically expensive processes as a collective only when the impact of those processes on the environment or on a host will be maximized. Among the many traits controlled by quorum sensing is the expression of virulence factors by pathogenic bacteria. Here we review the quorum-sensing circuits of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Vibrio cholerae. We outline these canonical quorum-sensing mechanisms and how each uniquely controls virulence factor production. Additionally, we examine recent efforts to inhibit quorum sensing in these pathogens with the goal of designing novel antimicrobial therapeutics.

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          Author and article information

          Journal
          Cold Spring Harb Perspect Med
          Cold Spring Harbor perspectives in medicine
          Cold Spring Harbor Laboratory
          2157-1422
          2157-1422
          Nov 01 2012
          : 2
          : 11
          Affiliations
          [1 ] Department of Molecular Biology, Princeton University, New Jersey 08544, USA.
          Article
          2/11/a012427
          10.1101/cshperspect.a012427
          3543102
          23125205
          bb5cded4-f82d-43ba-9a13-0099a5967a12
          History

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