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The SUN Rises on Meiotic Chromosome Dynamics
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Abstract
Recent studies in diverse eukaryotes have implicated a family of nuclear envelope
proteins containing SUN domains as key components of meiotic nuclear organization
and chromosome dynamics. In many cases, these transmembrane proteins are also known
to contribute to centrosome or spindle pole body function in mitotically dividing
cells. During meiotic prophase, the apparent role of these SUN-domain proteins, together
with their partner KASH-domain proteins, is to connect chromosomes through the intact
nuclear envelope to force-generating mechanisms in the cytoplasm.