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      Effects of dexamethasone and colostrum intake on the somatotropic axis in neonatal calves.

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          Abstract

          Glucocorticoids and colostrum feeding influence postnatal maturation of the somatotropic axis. We have tested the hypothesis that dexamethasone (Dexa) affects the somatotropic axis in neonatal calves dependent on colostrum intake. Calves were fed either with colostrum or with a milk-based formula (n = 14/group), and, in each feeding group, one-half of the calves were treated with Dexa (30 micro g. kg body wt-1. day-1). Pre- and postprandial blood samples were taken on days 1, 2, 4, and 5, and liver samples were taken on day 5 of life. Dexa increased insulin-like growth factor (IGF)-I, but decreased growth hormone (GH) and IGF-binding protein (IGFBP)-1 and -2 plasma concentrations and increased GH receptor (GHR) mRNA levels in liver. Dexa increased IGF-I mRNA levels only in formula-fed calves and increased hepatic GHR binding capacity, but only in colostrum-fed calves. Colostrum feeding decreased IGFBP-1 and -2 plasma concentrations and hepatic IGFBP-2 and -3 mRNA levels. In conclusion, Dexa and colostrum feeding promoted maturation of the somatotropic axis. Dexa effects partly depended on whether colostrum was fed or not.

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          Author and article information

          Journal
          Am. J. Physiol. Endocrinol. Metab.
          American journal of physiology. Endocrinology and metabolism
          American Physiological Society
          0193-1849
          0193-1849
          Aug 2003
          : 285
          : 2
          Affiliations
          [1 ] Div. of Animal Nutrition and Physiology, Univ. of Berne, Route de la Tioleyre 4, CH-1725 Posieux, Switzerland.
          Article
          00557.2002
          10.1152/ajpendo.00557.2002
          12670838
          bb7e8d01-eab4-4694-a97a-2b451af7b541
          History

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