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2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial
William E Kraus ,
Manjushri Bhapkar ,
Kim M Huffman ,
Carl F Pieper ,
Sai Krupa Das ,
Leanne M Redman ,
Dennis T Villareal ,
James Rochon ,
Susan B Roberts ,
Eric Ravussin ,
John O Holloszy ,
Luigi Fontana
July 2019
July 2019
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Abstract
For several cardiometabolic risk factors, values considered within normal range are
associated with an increased risk of cardiovascular morbidity and mortality. We aimed
to investigate the short-term and long-term effects of calorie restriction with adequate
nutrition on these risk factors in healthy, lean, or slightly overweight young and
middle-aged individuals.