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      Predictive value of a new radiotherapy plan evaluation tool for bladder toxicity in cervical cancer

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          Abstract

          Objective To evaluate the predictive value of a dose-surface histogram (DSH) for radiation cystitis (RC) in patients with cervical cancer.

          Methods We retrospectively included 190 patients with cervical cancer who underwent image-guided radiotherapy (IGRT) from the HIS system of The First Affiliated Hospital of Hebei North University from May 2013 to May 2023. The patients were divided into test group ( n = 100) and control group ( n = 90). The dose distribution in the bladder was evaluated by using a DSH for the test group and using a dose-volume histogram (DVH) for the control group. Receiver operating characteristic curves were used to evaluate the predictive value of DSH for RC in comparison with DVH.

          Results There were no significant differences in baseline data and RC incidence between the two groups (all P>0.05). All evaluation indicators were significantly different between DSH and DVH (all P<0.05). The predictive value of S 45 and V 45 for the incidence of grade-I, -II, and -III RC was low (all P<0.05). The predictive value of S 50 and V 50 for the incidence of grade-I, -II, and -III RC was moderate (all P<0.05). S 55S 57 and V 55V 57 showed high value for predicting the incidence of grade-I, -II, and -III RC (all P<0.05).

          Conclusion DSH shows basically the same predictive value for the incidence of RC caused by IGRT in cervical cancer as DVH, which is expected to become a new tool for evaluating radiotherapy plans.

          Abstract

          摘要: 目的 评价剂量表面积直方图(dose and surface histogram, DSH)对宫颈癌患者放射性膀胱炎(radiation cystitis, RC)的预测价值。 方法 筛选 2013 年 5 月—2023 年 5 月河北北方学院附属第一医院 HIS 系统接受图像引导放疗的 宫颈癌患者 190 例, 将患者分为试验组( n = 100)和对照组( n = 90), 收集其资料行回顾性研究。分别采用 DSH 和剂量 体积直方图(dose and volume histogram, DVH)评价试验组和对照组患者膀胱剂量分布。以 DVH 为参考, 采用受试者 工作特征曲线评价 DSH 对 RC 的预测价值。 结果 2 组基线资料和 RC 发生率比较差异均无统计学意义(均 P>0.05)。DSH 同 DVH 各项评价指标比较差异均有统计学意义(均 P<0.05)。 S 45V 45 对Ⅰ、Ⅱ、Ⅲ级 RC 发生率 的预测价值均为低等(均 P<0.05); S 50V 50 对Ⅰ、Ⅱ、Ⅲ级 RC 发生率的预测价值均为中等(均 P<0.05); S 55S 57V 55V 57 对Ⅰ、Ⅱ、Ⅲ级 RC 发生率的预测价值均为高等(均 P<0.05)。 结论 同 DVH 相比, DSH 对宫颈 癌 IGRT 致 RC 发生率的预测价值同其基本一致, 未来有望成为新的放疗计划评价工具。

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          Author and article information

          Journal
          CJRH
          Chinese Journal of Radiological Health
          Chinese Preventive Medical Association (Ji’an, China )
          1004-714X
          01 April 2024
          01 May 2024
          : 33
          : 2
          : 189-194
          Affiliations
          [1] 1Medical Imaging Center, the First Affiliated Hospital of Hebei Northern University, Zhangjiakou 075000 China
          Author notes
          Corresponding author: ZHU Yuexiang, E-mail: zjkxhtl@ 123456126.com
          Article
          j.issn.1004-714X.2024.02.014
          10.13491/j.issn.1004-714X.2024.02.014
          bb95ed70-da47-45b4-b07d-8c4969c0293e
          © 2024 Chinese Journal of Radiological Health

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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          Categories
          Journal Article

          Medicine,Image processing,Radiology & Imaging,Bioinformatics & Computational biology,Health & Social care,Public health
          Dose-surface histogram,Dose-volume histogram,Prediction,Cervical cancer,Radiation cystitis

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