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      Effect of Starvation on Pituitary Growth Hormone Cells and Blood Growth Hormone and Prolactin Levels in the Rat

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          Abstract

          Growth hormone (GH) cells of rats were studied on days 2, 4 and 7 of starvation. Immunoperoxidase staining for light microscopy confirmed the presence of GH in the pituitaries of all groups of animals. Electron microscopy revealed crinophagy in the cytoplasm of GH cells on days 4 and 7. By ultrastructural morphometry, volume density and the diameter of secretory granules in the cytoplasm of GH cells remained unchanged. Blood GH determinations showed a significant decrease on day 4 of the starvation period. On day 7 most of the values were in the range of the controls. Blood prolactin levels fell significantly on day 7. It appears that the pituitary is capable of secreting GH even in rats completely deprived of exogenous nutrients.

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          Author and article information

          Journal
          ANM
          Ann Nutr Metab
          10.1159/issn.0250-6807
          Annals of Nutrition and Metabolism
          S. Karger AG
          0250-6807
          1421-9697
          1976
          1976
          13 November 2008
          : 20
          : 1
          : 67-75
          Affiliations
          Department of Pathology, University of Toronto, Banting Institute, Toronto, Ont., and Departments of Medicine and Pathology, University of Toronto, St. Michael’s Hospital, Toronto, Ont.
          Article
          175688 Nutr Metab 1976;20:67–75
          10.1159/000175688
          bb97e8f6-9702-4d10-939b-f19da34c31cd
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 08 December 1975
          : 16 February 1976
          Page count
          Pages: 9
          Categories
          Paper

          Nutrition & Dietetics,Health & Social care,Public health
          Starvation,Pituitary morphology,Growth hormone,Prolactin,Pituitary

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