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      Iontophoresis of amoxicillin and cefuroxime: rapid therapeutic concentrations in skin

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      Drug Development and Industrial Pharmacy

      Informa UK Limited

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          Most cited references 15

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          Iontophoretic drug delivery.

          The composition and architecture of the stratum corneum render it a formidable barrier to the topical and transdermal administration of therapeutic agents. The physicochemical constraints severely limit the number of molecules that can be considered as realistic candidates for transdermal delivery. Iontophoresis provides a mechanism to enhance the penetration of hydrophilic and charged molecules across the skin. The principal distinguishing feature is the control afforded by iontophoresis and the ability to individualize therapies. This may become significant as the impact of interindividual variations in protein expression and the effect on drug metabolism and drug efficacy is better understood. In this review we describe the underlying mechanisms that drive iontophoresis and we discuss the impact of key experimental parameters-namely, drug concentration, applied current and pH-on iontophoretic delivery efficiency. We present a comprehensive and critical review of the different therapeutic classes and molecules that have been investigated as potential candidates for iontophoretic delivery. The iontophoretic delivery of peptides and proteins is also discussed. In the final section, we describe the development of the first pre-filled, pre-programmed iontophoretic device, which is scheduled to be commercialized during the course of 2004.
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            Bacillus anthracis

             R Spencer (2003)
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              The stability of amoxycillin, clarithromycin and metronidazole in gastric juice: relevance to the treatment of Helicobacter pylori infection

               P. Erah,  Nick Shaw (1997)
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                Author and article information

                Journal
                Drug Development and Industrial Pharmacy
                Drug Development and Industrial Pharmacy
                Informa UK Limited
                0363-9045
                1520-5762
                August 30 2013
                March 2014
                January 25 2013
                March 2014
                : 40
                : 3
                : 325-329
                Article
                10.3109/03639045.2012.760579
                © 2014

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