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      Programming Algorithms for Sacral Neuromodulation: Clinical Practice and Evidence—Recommendations for Day‐to‐Day Practice

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          Abstract

          Background

          In sacral neuromodulation (SNM), stimulation programming plays a key role to achieve success of the therapy. However to date, little attention has been given to the best ways to set and optimize SNM programming during the test and chronic stimulation phases of the procedure.

          Objective

          Standardize and make SNM programming easier and more efficient for the several conditions for which SNM is proposed.

          Methods

          Systematic literature review and collective clinical experience report.

          Results

          The basic principles of SNM programming are described. It covers choice of electrode configuration, stimulation amplitude, pulse frequency and pulse widths, while use of cycling is also briefly discussed. Step‐by‐step practical flow charts developed by a group of 13 European experts are presented.

          Conclusions

          Programming of SNM therapy is not complex. There are few programming settings that seem beneficial or significantly impact patient outcomes. Only four basic electrode configurations could be identified according to four different options to define the cathode. In a majority of patients, the proposed stimulation parameters will allow a satisfactory improvement for long periods of time. A regular follow‐up is, however, necessary to assess and eventually optimize results, as well as to reassure patients.

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          Most cited references51

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          Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

          Systematic reviews should build on a protocol that describes the rationale, hypothesis, and planned methods of the review; few reviews report whether a protocol exists. Detailed, well-described protocols can facilitate the understanding and appraisal of the review methods, as well as the detection of modifications to methods and selective reporting in completed reviews. We describe the development of a reporting guideline, the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015). PRISMA-P consists of a 17-item checklist intended to facilitate the preparation and reporting of a robust protocol for the systematic review. Funders and those commissioning reviews might consider mandating the use of the checklist to facilitate the submission of relevant protocol information in funding applications. Similarly, peer reviewers and editors can use the guidance to gauge the completeness and transparency of a systematic review protocol submitted for publication in a journal or other medium.
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            Basic algorithms for the programming of deep brain stimulation in Parkinson's disease.

            The clinical success of deep brain stimulation (DBS) for treating Parkinson's disease (PD) critically depends on the quality of postoperative neurological management. Movement disorder specialists becoming involved with this therapy need to acquire new skills to adapt optimally stimulation parameters and medication after implantation of a DBS system. At first glance, the infinite number of theoretically possible parameter combinations seems to make programming a complex and time-consuming art. This article outlines a stepwise and standardized approach, reducing the possible parameter settings in DBS to a few relevant combinations. The basic programming algorithms for thalamic, subthalamic, and pallidal stimulation in PD are explained and summarized in flowcharts.
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              Electrical stimulation of sacral spinal nerves for treatment of faecal incontinence.

              Functional deficits of the striated anal sphincteric muscles without any apparent gross defect often result in a lack of ability to postpone defaecation by intention or in faecal incontinence in response to increased intra-abdominal or intra-rectal pressure. We applied electrostimulation to the sacral spinal nerves to increase function of the striated muscles of the anal sphincter. Of three patients followed for 6 months, two gained full continence and one improved from gross incontinence to minor soiling. Closure pressure of the anal canal increased in all. Preliminary data indicate that anal closure pressure increases with the duration of stimulation. Continuous stimulation of sacral spinal nerves can help some patients with faecal incontinence. It may be possible to promote continence with intermittent stimulation.
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                Author and article information

                Contributors
                dr.pa.lehur@gmail.com , paul-antoine.lehur@eoc.net
                Journal
                Neuromodulation
                Neuromodulation
                10.1111/(ISSN)1525-1403
                NER
                Neuromodulation
                John Wiley & Sons, Inc. (Hoboken, USA )
                1094-7159
                1525-1403
                09 March 2020
                December 2020
                : 23
                : 8 ( doiID: 10.1111/ner.v23.8 )
                : 1121-1129
                Affiliations
                [ 1 ] Coloproctology Unit Ospedale Regionale di Lugano Lugano Switzerland
                [ 2 ] Department of Surgical and Medical Gastroenterology Hvidovre University Hospital Hvidovre Denmark
                [ 3 ] Department of Gastrointestinal Surgery University Hospital Southampton Southampton UK
                [ 4 ] Centre for Neuroscience, Surgery and Trauma Blizard Institute, Queen Mary University of London, Barts Health NHS Trust London UK
                [ 5 ] Department of Urology University Hospital Antwerpen Antwerpen Belgium
                [ 6 ] Faculty of Health Sciences University of Antwerpen Antwerpen Belgium
                [ 7 ] Medtronic International Trading Sarl Tolochenaz Switzerland
                [ 8 ] Chirurgische Klinik, Universität Erlangen Erlangen Germany
                Author notes
                [*] [* ]Address correspondence to: Paul‐Antoine Lehur, MD, PhD, Ospedale Regionale di Lugano, 6900 Lugano, Svizzera. Email: dr.pa.lehur@ 123456gmail.com , paul-antoine.lehur@ 123456eoc.net
                Author information
                https://orcid.org/0000-0001-8943-7062
                https://orcid.org/0000-0001-5903-1037
                Article
                NER13117
                10.1111/ner.13117
                7818413
                32153080
                bba121c4-d3e3-4a6c-873e-ba47cd236f90
                © 2020 The Authors. Neuromodulation: Technology at the Neural Interface published by Wiley Periodicals, Inc. on behalf of International Neuromodulation Society.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                : 14 October 2019
                : 03 December 2019
                : 14 January 2020
                Page count
                Figures: 4, Tables: 1, Pages: 9, Words: 7314
                Funding
                Funded by: Medtronic , open-funder-registry 10.13039/100004374;
                Categories
                Review Article
                Review Articles
                Custom metadata
                2.0
                December 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.6 mode:remove_FC converted:21.01.2021

                basic programming,electric stimulation,fecal incontinence,pelvic organ dysfunction,sacral neuromodulation,urinary incontinence

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