68Ga-DOTATATE PET/CT in the Localization of Head and Neck Paragangliomas Compared with Other Functional Imaging Modalities and CT/MRI.

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Abstract

Pheochromocytomas/paragangliomas overexpress somatostatin receptors, and recent studies have already shown excellent results in the localization of sympathetic succinate dehydrogenase complex, subunit B, mutation-related metastatic pheochromocytomas/paragangliomas using (68)Ga-DOTATATE PET/CT. Therefore, the goal of our study was to assess the clinical utility of this functional imaging modality in parasympathetic head and neck paragangliomas (HNPGLs) compared with anatomic imaging with CT/MRI and other functional imaging modalities, including (18)F-fluorohydroyphenylalanine ((18)F-FDOPA) PET/CT, currently the gold standard in the functional imaging of HNPGLs.

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Journal

Journal ID (iso-abbrev): J. Nucl. Med.

Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Publisher: Society of Nuclear Medicine

ISSN (Electronic): 1535-5667

ISSN (Print): 0161-5505

Publication date (Electronic): Feb 2016

Volume: 57

Issue: 2

Affiliations

[1 ] Program in Adult and Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland Section of Nuclear Medicine, Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Lübeck, Germany.

[2 ] Nuclear Medicine Division, Radiology & Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland.

[3 ] Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.

[4 ] Section of Neuroradiology, Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland.

[5 ] Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland.

[6 ] Program in Adult and Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

[7 ] Endocrine Oncology Branch, National Cancer Institute, Bethesda, Maryland; and.

[8 ] Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

[9 ] Section of Nuclear Medicine, Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Lübeck, Germany.

[10 ] Program in Adult and Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland karel@mail.nih.gov.

Article

Publisher Item ID: jnumed.115.161018 Mid ID: NIHMS710611

DOI: 10.2967/jnumed.115.161018

PMC ID: 4738157

PubMed ID: 26564322

SO-VID: bba6f8b1-1b7b-4db8-8bb3-83982074541c

History

Keywords: 68Ga-DOTATATE,18F-FDOPA,head and neck paraganglioma

Data availability:

Keywords: 68Ga-DOTATATE, 18F-FDOPA, head and neck paraganglioma

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