To study the epidemiology and pregnancy outcome of pre-eclampsia at Ain Shams University Hospital for Obstetrics and Gynecology. A case control study involved 995 cases of pre-eclampsia, 227 cases with chronic hypertension and 1375 cases with normal pregnancy delivered during the year 2000 at Ain Shams University Maternity Hospital. All these cases were critically analyzed regarding to some risk factors as age, parity, blood group, diabetes mellitus, Rhesus factor and multiple pregnancy. The outcomes of all these 3 groups were compared regarding to maternal and fetal morbidity and mortality. Pre-eclampsia was more common in elder age, blood group B, in Rhesus negative, during summer, multiple pregnancy and in patients with diabetes mellitus. The difference was statistically significant regarding all these risk factors (p < 0.01) when compared with cases of chronic hypertension and patients with normal pregnancies. In this work pre-eclampsia was found to be an important cause for maternal and fetal mortality. Also it was found to be an important cause for premature deliveries.