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Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial
Luis Paz-Ares ,
Mikhail Dvorkin ,
Yuanbin Chen ,
Niels Reinmuth ,
Katsuyuki Hotta ,
Dmytro Trukhin ,
Galina Statsenko ,
Maximilian J Hochmair ,
Mustafa Özgüroğlu ,
Jun Ho Ji ,
Oleksandr Voitko ,
Artem Poltoratskiy ,
Santiago Ponce ,
Francesco Verderame ,
Libor Havel ,
Igor Bondarenko ,
Andrzej Kazarnowicz ,
György Losonczy ,
Nikolay V Conev ,
Jon Armstrong ,
Natalie Byrne ,
Norah Shire ,
Haiyi Jiang ,
Jonathan W Goldman ,
Emilio Batagelj ,
Ignacio Casarini ,
Anea Viviana Pastor ,
Susana Noemi Sena ,
Juan Jose Zarba ,
Otto Burghuber ,
Sylvia Hartl ,
Maximilian J Hochmair ,
Bernd Lamprecht ,
Michael Studnicka ,
Luis Alberto Schlittler ,
Fabricio Augusto Martinelli de Oliveira ,
Aknar Calabrich ,
Gustavo Colagiovanni Girotto ,
Peo Dos Reis ,
Carlos Fausto Nino Gorini ,
Peo Rafael Martins De Marchi ,
Clarissa Serodio da Rocha Baldotto ,
Claudia Sette ,
Mauro Zukin ,
Nikolay V Conev ,
Assen Dudov ,
Rumyana Ilieva ,
Krassimir Koynov ,
Rositsa Krasteva ,
Ivan Tonev ,
Spartak Valev ,
Violetka Venkova ,
Minghong Bi ,
Chengshui Chen ,
Yuan Chen ,
Zhendong Chen ,
Jian Fang ,
Jifeng Feng ,
Zhigang Han ,
Jie Hu ,
Yi Hu ,
Wei Li ,
Zongan Liang ,
Zhong Lin ,
Rui Ma ,
Shenglin Ma ,
Kejun Nan ,
Yongqian Shu ,
Kai Wang ,
Mengzhao Wang ,
Gang Wu ,
Nong Yang ,
Zhixiong Yang ,
Helong Zhang ,
Wei Zhang ,
Jun Zhao ,
Yanqiu Zhao ,
Caicun Zhou ,
Jianying Zhou ,
Xiangdong Zhou ,
Libor Havel ,
Vitezslav Kolek ,
Leona Koubkova ,
Jaromir Roubec ,
Jana Skrickova ,
Milada Zemanova ,
Christos Chouaid ,
Werner Hilgers ,
Hervé Lena ,
Denis Moro-Sibilot ,
Gilles Robinet ,
Pierre-Jean Souquet ,
Jürgen Alt ,
Helge Bischoff ,
Christian Grohe ,
Eckart Laack ,
Susanne Lang ,
Jens Panse ,
Niels Reinmuth ,
Christian Schulz ,
Krisztina Bogos ,
Eszter Csánky ,
Anea Fülöp ,
Zsolt Horváth ,
Judit Kósa ,
Ibolya Laczó ,
György Losonczy ,
Gábor Pajkos ,
Zsuzsanna Pápai ,
Zsolt Pápai Székely ,
Veronika Sárosi ,
Attila Somfay ,
Éva Somogyiné Ezer ,
Anás Telekes ,
Jair Bar ,
Maya Gottfried ,
Norman Isaac Heching ,
Alona Zer Kuch ,
Roberta Bartolucci ,
Anna Cecilia Bettini ,
Angelo Delmonte ,
Marina Chiara Garassino ,
Mauro Minelli ,
Fausto Roila ,
Francesco Verderame ,
Shinji Atagi ,
Koichi Azuma ,
Hisatsugu Goto ,
Koichi Goto ,
Yu Hara ,
Hidetoshi Hayashi ,
Toyoaki Hida ,
Katsuyuki Hotta ,
Kenya Kanazawa ,
Shintaro Kanda ,
Young Hak Kim ,
Shoichi Kuyama ,
Tadashi Maeda ,
Masahiro Morise ,
Yasuharu Nakahara ,
Makoto Nishio ,
Naoyuki Nogami ,
Isamu Okamoto ,
Haruhiro Saito ,
Masahiro Shinoda ,
Shigeki Umemura ,
Tatsuya Yoshida ,
Niels Claessens ,
Robin Cornelissen ,
Lizza Heniks ,
Jeroen Hiltermann ,
Egbert Smit ,
Agnes Staal van den Brekel ,
Andrzej Kazarnowicz ,
Dariusz Kowalski ,
Slawomir Mańdziuk ,
Robert Mróz ,
Marek Wojtukiewicz ,
Tudor Ciuleanu ,
Doina Ganea ,
Anei Ungureanu ,
Mikhail Dvorkin ,
Alexander Luft ,
Vladimir Moiseenko ,
Artem Poltoratskiy ,
Dina Sakaeva ,
Alexey Smolin ,
Galina Statsenko ,
Alexander Vasilyev ,
Lyubov Vladimirova ,
Igor Anasina ,
Jozef Chovanec ,
Pavol Demo ,
Robert Godal ,
Peter Kasan ,
Marian Stresko ,
Michal Urda ,
Eun Kyung Cho ,
Jun Ho Ji ,
Joo-Hang Kim ,
Sang-We Kim ,
Gyeong-Won Lee ,
Jong-Seok Lee ,
Ki Hyeong Lee ,
Kyung Hee Lee ,
Yun Gyoo Lee ,
Maria Amelia Insa Molla ,
Manuel Domine Gomez ,
Juan Ignacio Delgado Mingorance ,
Dolores Isla Casado ,
Marta Lopez Brea ,
Margarita Majem Tarruella ,
Teresa Morán Bueno ,
Alejano Navarro Mendivil ,
Luis Paz-Ares Rodríguez ,
Santiago Ponce Aix ,
Maria Rosario Garcia Campelo ,
Gee-Chen Chang ,
Yen-Hsun Chen ,
Chao-Hua Chiu ,
Te-Chun Hsia ,
Kang-Yun Lee ,
Chien-Te Li ,
Chin-Chou Wang ,
Yu-Feng Wei ,
Shang-Yin Wu ,
Ahmet Alacacıoğlu ,
Irfan Çiçin ,
Ahmet Demirkazik ,
Mustafa Erman ,
Tuncay Göksel ,
Mustafa Özgüroğlu ,
Hryhoriy Adamchuk ,
Igor Bondarenko ,
Oleksii Kolesnik ,
Anna Kryzhanivska ,
Yuriv Ostapenko ,
Serhii Shevnia ,
Yaroslav Shparyk ,
Dmytro Trukhin ,
Grygorii Ursol ,
Nataliia Voitko ,
Oleksandr Voitko ,
Ihor Vynnychenko ,
Sunil Babu ,
Yuanbin Chen ,
Anne Chiang ,
Winston Chua ,
Shaker Dakhil ,
Afshin Dowlati ,
Jonathan W Goldman ,
Basir Haque ,
Rodney Jamil ,
Jeanna Knoble ,
Shailena Lakhanpal ,
Kailhong Mi ,
Petros Nikolinakos ,
Steven Powell ,
Helen Ross ,
Eric Schaefer ,
Jeffrey Schneider ,
Joseph Spahr ,
David Spigel ,
Joseph Stilwill ,
Christopher Sumey ,
Michael Williamson
October 2019
October 2019
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Most patients with small-cell lung cancer (SCLC) have extensive-stage disease at presentation,
and prognosis remains poor. Recently, immunotherapy has demonstrated clinical activity
in extensive-stage SCLC (ES-SCLC). The CASPIAN trial assessed durvalumab, with or
without tremelimumab, in combination with etoposide plus either cisplatin or carboplatin
(platinum-etoposide) in treatment-naive patients with ES-SCLC.