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      Cytokines in the Central Nervous System: Regulatory Roles in Neuronal Function, Cell Death and Repair

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          Abstract

          Recent evidence suggests that neurons and glia can synthesize and secrete cytokines, which play critical roles in maintaining homeostasis in the central nervous system (CNS) by mediating the interaction between cells via autocrine or paracrine mechanisms. Circulating cytokines and soluble receptors also regulate neuronal function via endocrine mechanisms. Disturbance of the cytokine-mediated interaction between cells may lead to neuronal dysfunction and/or cell death and contribute to the pathogenesis of the CNS diseases (e. g., ischemia, Alzheimer''s disease and HIV encephalopathy). Defining the molecular pathways of cytokine dysregulation and neurotoxicity may help to elucidate potential therapeutic interventions for many devastating CNS diseases.

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          Author and article information

          Journal
          NIM
          Neuroimmunomodulation
          10.1159/issn.1021-7401
          Neuroimmunomodulation
          S. Karger AG
          1021-7401
          1423-0216
          1995
          1995
          20 November 1995
          : 2
          : 3
          : 121-133
          Affiliations
          aLaboratory of Neuroscience, National Institute of Diabetes, Digestive and Kidney Diseases, and bDivision of Neuroscience and Behavioral Science, National Institute of Mental Health, National Institutes of Health, Bethesda,Md.,USA,and cDepartment of Virology, Kagoshima University School of Medicine, Kagoshima, Japan
          Article
          96881 Neuroimmunomodulation 1995;2:121–133
          10.1159/000096881
          8646560
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 13
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          Review

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