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      Presentation of retinoblastoma in pregnancy

      case-report

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A 22-year-old female in her third trimester of pregnancy was referred to our department for sudden loss of vision with a painful blind eye. It was diagnosed as retinoblastoma clinically and radiologically. Histopathology and immunohistochemistry confirmed the diagnosis. This case is one of its kind because retinoblastoma occurring during pregnancy had not been reported in literature so far.

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          Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product.

          A. L. Yen, K Mihara, Colin Murphree … (1989)
          The human retinoblastoma gene (RB1) encodes a protein (Rb) of 105 kilodaltons that can be phosphorylated. Analysis of Rb metabolism has shown that the protein has a half-life of more than 10 hours and is synthesized at all phases of the cell cycle. Newly synthesized Rb is not extensively phosphorylated (it is "underphosphorylated") in cells in the G0 and G1 phases but is phosphorylated at multiple sites at the G1/S boundary and in S phase. HL-60 cells that were induced to terminally differentiate by various chemicals lost their ability to phosphorylate newly synthesized Rb at multiple sites when cell growth was arrested. These findings suggest that underphosphorylated Rb may restrict cell proliferation.
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            Observations on 17 patients with retinocytoma.

            Emily J. Shields, J Eagle, Ashutosh Singh … (2000)
            To study the clinical features and natural history of 17 patients with retinocytoma. A retrospective case series. Tertiary referral center. Data on 17 patients with retinocytoma were reviewed for clinical features. The natural history of retinocytoma and its risk for malignant transformation were also evaluated. Among 920 consecutive patients who had retinoblastoma, retinocytoma, or both, we identified 24 tumors in 17 patients (1.8%) with clinical features compatible with retinocytoma. The median age at diagnosis was 15 years (range, 4-45 years). Of the 24 tumors, the retinocytoma was bilateral in 3 cases (13%) and the family history of retinoblastoma was positive in 3 cases (13%). Seventeen (71%) of the tumors were extramacular in location, and 7 (29%) were located in the macular area. Ophthalmoscopic features characteristic of retinocytoma included the presence of a translucent retinal mass in 21 (88%), calcification in 15 (63%), and retinal pigment epithelial alteration in 13 (54%) of the 24 tumors. A combination of all 3 features was observed in 8 (33%) of the 24 tumors. In 13 (54%) of the tumors, a zone of chorioretinal atrophy could be observed. In 1 patient, subtle tumor regression was documented photographically. Only 1 retinocytoma (4%) underwent malignant transformation into retinoblastoma. At the last follow-up visit, none of the patients had developed a pineoblastoma or another second malignant neoplasm. Retinocytoma is a rare benign retinal tumor that has characteristic clinical features. The areas of chorioretinal atrophy were suggestive of tumor regression. In our series, the risk for malignant transformation of retinocytoma into retinoblastoma was 4%; therefore, patients with a presumed diagnosis of retinocytoma should be closely observed.
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              Cancer in pregnancy: a review of the literature. Part I.

              Massimo Antonelli, D J Dotters, Ralph V Katz … (1996)
              Cancer is an important cause of death in the United States in women of childbearing age. Approximately 1 per 1000 pregnant women will develop cancer. This review (Part II follows in this issue) examines the diagnosis, prognosis, and management of cancer during pregnancy; both in terms of the cancer's effect on the pregnancy, and the pregnancy's effect on the cancer. Some diagnostic modalities and some therapies are problematic to the fetus and placenta. However, in most cases and the pregnancy can be managed concurrently with a good outcome for the baby and without compromising the mother's prognosis.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Indian J Ophthalmol
                Journal ID (publisher-id): IJO
                Title: Indian Journal of Ophthalmology
                Publisher: Medknow Publications (India )
                ISSN (Print): 0301-4738
                ISSN (Electronic): 1998-3689
                Publication date (Print): May-Jun 2010
                Volume: 58
                Issue: 3
                Pages: 229-232
                Affiliations
                Department of Ophthalmology, Government Medical college, Aurangabad, Maharashtra, India
                Author notes
                Correspondence to: Dr. Varsha S. Nandedkar (Associate Professor), Department of Ophthalmology, Government Medical College, Aurangabad-431 001, India. E-mail: vsnandedkar@ 123456yahoo.co.in
                Article
                Publisher ID: IJO-58-229
                DOI: 10.4103/0301-4738.62649
                PMC ID: 2886255
                PubMed ID: 20413927
                SO-VID: bbd2ec55-55e8-4020-9252-0523069b2e64
                Copyright © © Indian Journal of Ophthalmology
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 23 June 2009
                Date accepted : 24 November 2009
                Categories
                Subject: Brief Communications

                ScienceOpen disciplines: Ophthalmology & Optometry
                Keywords: retinoblastoma,flexner-wintersteiner rosettes,immunohistochemistry,chemoreduction,homer-wright rosettes,enucleation
                Data availability:
                ScienceOpen disciplines: Ophthalmology & Optometry
                Keywords: retinoblastoma, flexner-wintersteiner rosettes, immunohistochemistry, chemoreduction, homer-wright rosettes, enucleation

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