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      Targeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective Strategy to Inhibit Tumor Cell Proliferation

      1 , 1 , 1
      Current Cancer Drug Targets
      Bentham Science Publishers Ltd.

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          Abstract

          Targeting highly proliferating cells is an important issue for many types of aggressive tumors. Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety of processes of DNA metabolism, including DNA replication and repair, chromatin organization and transcription and sister chromatid cohesion. In addition, PCNA is involved in cell survival, and possibly in pathways of energy metabolism, such as glycolysis. Thus, the possibility of targeting this protein for chemotherapy against highly proliferating malignancies is under active investigation. Currently, approaches to treat cells with agents targeting PCNA rely on the use of small molecules or on peptides that either bind to PCNA, or act as a competitor of interacting partners. Here, we describe the status of the art in the development of agents targeting PCNA and discuss their application in different types of tumor cell lines and in animal model systems.

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          Author and article information

          Contributors
          (View ORCID Profile)
          Journal
          Current Cancer Drug Targets
          CCDT
          Bentham Science Publishers Ltd.
          15680096
          April 30 2020
          April 30 2020
          : 20
          : 4
          : 240-252
          Affiliations
          [1 ]Istituto di Genetica Molecolare del C.N.R. “Luca Cavalli-Sforza”, Pavia- 27100, Italy
          Article
          10.2174/1568009620666200115162814
          31951183
          bbe0d53f-e669-4df6-8017-283fd8e33004
          © 2020
          History

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