Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials.

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Abstract

Four new oral anticoagulants compare favourably with warfarin for stroke prevention in patients with atrial fibrillation; however, the balance between efficacy and safety in subgroups needs better definition. We aimed to assess the relative benefit of new oral anticoagulants in key subgroups, and the effects on important secondary outcomes.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Mar 15 2014

Volume: 383

Issue: 9921

Affiliations

[1 ] Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: cruff@partners.org.

[2 ] Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

[3 ] Jefferson Medical College, Philadelphia, PA, USA; Cardiovascular Research Foundation, New York, NY, USA.

[4 ] St George's University, London, UK.

[5 ] McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada.

[6 ] Lady Davis Carmel Medical Center, Haifa, Israel.

[7 ] Institute of Cardiology, Kiev, Ukraine.

[8 ] The Cardiovascular Institute, Tokyo, Japan.

Article

Publisher Item ID: S0140-6736(13)62343-0

DOI: 10.1016/S0140-6736(13)62343-0

PubMed ID: 24315724

SO-VID: bbeaab96-7b97-448a-bb67-288f2b0552f4

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