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      Mechanistic applications of click chemistry for pharmaceutical drug discovery and drug delivery.

      1 , 1 , 2
      Drug discovery today
      Elsevier BV

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          Abstract

          The concept of click chemistry (CC), first introduced by K.B. Sharpless, has been widely adopted for use in drug discovery, novel drug delivery systems (DDS), polymer chemistry, and material sciences. In this review, we outline novel aspects of CC related to drug discovery and drug delivery, with a brief overview of molecular mechanisms underlying each click reaction commonly used by researchers, and the main patents that paved the way for further diverse medicinal applications. We also describe recent progress in drug discovery and polymeric and carbon material-based drug delivery for potential pharmaceutical applications and advancements based on the CC approach, and discuss some intrinsic limitations of this popular conjugation reaction. The use of CC is likely to significantly advance drug discovery and bioconjugation development.

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          Author and article information

          Journal
          Drug Discov. Today
          Drug discovery today
          Elsevier BV
          1878-5832
          1359-6446
          Nov 2017
          : 22
          : 11
          Affiliations
          [1 ] College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.
          [2 ] College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea; Institute of Pharmaceutical Science and Technology, Ajou University, Suwon 16499, Republic of Korea. Electronic address: bjl@ajou.ac.kr.
          Article
          S1359-6446(17)30103-4
          10.1016/j.drudis.2017.07.007
          28754291
          bbf7ce5f-3f8e-44ef-af12-37938abf5b0a

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