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      Glomerular Expression of α2(IV) and α5(IV) Chains of Type IV Collagen in Patients with IgA Nephropathy

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          Abstract

          IgA nephropathy (IgAN) frequently accompanies glomerular basement membrane (GBM) alterations. To clarify the compositional changes of the GBM in IgAN, we examined the glomerular expression of α2(IV) and α5(IV) chains of type IV collagen in 36 patients with IgAN. Increased expression of the α2(IV) chain was observed in the expanded mesangium, and there were segmental sclerotic lesions of glomeruli in which the expression of the α5(IV) chain in the GBM was reduced. These lesions were found in 11 out of the 36 patients (30.6%). The patients with these lesions had more proteinuria, lower creatinine clearance and severer histological changes than the patients without them. On the other hand, a partial reduction of α5(IV) chain in normal-appearing GBM was observed in 15 out of the 36 patients (41.7%). The patients with this lesion had a longer disease period before biopsy than the patients without it. No other clinical and histological parameters were related to the partial reduction of α5(IV) in the GBM. In conclusion, an imbalance of glomerular α2(IV) and α5(IV) chain expression occurred in IgAN. This may be associated with the morphological changes of glomerular sclerosis and GBM alterations in IgAN. Further studies are required to understand the pathogenesis of the abnormal expression of type IV collagen chains.

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          Complete primary structure of the α1-chain of human basement membrane (type IV) collagen

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            A Case of IgA Nephropathy with Split Reduction of α5(V) Chain of Type IV Collagen in Glomerular Basement Membrane

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              Author and article information

              Journal
              NEF
              Nephron
              10.1159/issn.1660-8151
              Nephron
              S. Karger AG
              1660-8151
              2235-3186
              2002
              May 2002
              02 May 2002
              : 91
              : 1
              : 43-50
              Affiliations
              aDepartment of Medicine, Kidney Center, Tokyo Women’s Medical University, Tokyo, and bDepartment of Pathology, Tokyo Jikei-kai Kashiwa Hospital, Chiba, Japan
              Article
              57603 Nephron 2002;91:43–50
              10.1159/000057603
              12021518
              © 2002 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 3, Tables: 3, References: 27, Pages: 8
              Product
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/57603
              Categories
              Original Paper

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