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      Intravitreal Trovafloxacin against Experimental Staphylococcus epidermidis Endophthalmitis

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          Abstract

          This study was designed to test the effects of intravitreal trovafloxacin on an experimental rabbit model of Staphylococcus epidermidis endophthalmitis. Out of 26 rabbits, 22 were given intravitreal S. epidermidis (100,000 CFU). At 24 h, group 1 (8 rabbits) and, at 48 h, group 2 (8 rabbits) received 100 µg intravitreal trovafloxacin. Group 3 (6 rabbits) was used as inoculated but untreated controls. Four rabbits (group 4) were used as uninfected controls. Clinical scores were calculated at 24, 48 and 72 h. Microbiological and histopathological scorings were made. Microbiological analysis showed that trovafloxacin administered at 24 or 48 h significantly reduced the number of bacteria compared to the untreated group. We conclude that trovafloxacin applied at 24 or 48 h is effective against S. epidermidis endophthalmitis in this experimental rabbit model.

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          Treatment of experimental Staphylococcus epidermidis endophthalmitis with oral trovafloxacin

          Eugene W.M. Ng, Nasrollah Samiy, Kathryn Ruoff … (1998)
          Article 0 comments Cited 6 times – based on 0 reviews     Review now
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            Author and article information

            Journal
            Journal ID (publisher-id): ORE
            Journal ID (nlm-ta): Ophthalmic Res
            Journal ID (doi): 10.1159/issn.0030-3747
            Title: Ophthalmic Research
            Publisher: S. Karger AG
            ISSN (Print): 0030-3747
            ISSN (Electronic): 1423-0259
            Publication date Subscription-year: 2000
            Publication date (Print): June 2000
            Publication date (Electronic): 10 April 2000
            Volume: 32
            Issue: 2-3
            Pages: 126-131
            Affiliations
            Departments of aOphthalmology, bMicrobiology and cPathology, Erciyes University Faculty of Medicine, Kayseri, Turkey
            Article
            Publisher ID: 55601 Other ID: Ophthalmic Res 2000;32:126–131
            DOI: 10.1159/000055601
            PubMed ID: 10754446
            SO-VID: bc1d7efc-f5da-407d-8bbb-008dc2ea278a
            Copyright © © 2000 S. Karger AG, Basel
            License:

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            History
            Page count
            Figures: 1, Tables: 2, References: 19, Pages: 6
            Categories
            Subject: Original Paper

            ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
            Keywords: Endophthalmitis,Intravitreal drug delivery,<italic>Staphylococcus epidermitis</italic>,Retina,antibiotics
            Data availability:
            ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
            Keywords: Endophthalmitis, Intravitreal drug delivery, <italic>Staphylococcus epidermitis</italic>, Retina, antibiotics

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