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      Concentration of Three Thrombin Inhibitors in the Nephrotic Syndrome in Adults

      , ,

      Nephron

      S. Karger AG

      Nephrotic syndrome, Antithrombin III, α1-Antitrypsin, α1-Macroglobulin

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          Abstract

          Plasma antithrombin III (AT III), α<sub>1</sub>-antitrypsin (α<sub>1</sub>-AT) and α<sub>1</sub>-macroglobulin (α<sub>1</sub>-M) concentrations were measured in 17 cases of the nephrotic syndrome (NS) in adults. The mean plasma level of AT III was normal. The AT III concentration was correlated with albuminaemia (r=+0.718, p < 0.005), cholesterolaemia (r= – 0.651, p < 0.005) as well as with urinary protein (r = – 0.531, p < 0.05). The α<sub>1</sub>-AT concentration was decreased (p < 0.01) and correlated with serum albumin level (r = + 0.643, p < 0.01). The α<sub>1</sub>-M concentration significantly increased (p < 0.001). A negative correlation of the α<sub>1</sub>-M level with serum albumin concentration (r= -0.561, p < 0.025) and a positive correlation with the cholesterol concentration (r= +0.819, p < 0.001) was found. AT III and α<sub>1</sub>-M were inversely correlated (r= –0.706, p < 0.005). It is considered that in NS in adults, the increase of α<sub>1</sub>-M is not compensatory for AT III, and there is no objection to the use of heparin in thrombosis prophylaxis with the exception of a few cases with very low AT III levels.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1986
          1986
          04 December 2008
          : 42
          : 3
          : 200-203
          Affiliations
          Nephrology Department Medical School, Białystok, Poland
          Article
          183667 Nephron 1986;42:200–203
          10.1159/000183667
          2418377
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
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          Original Paper

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