Hepatoprotective Activity of Oxalis stricta linn. on Paracetamol Induced Hepatotoxicity in Albino Rats

Abstract

This study was designed to determine the hepatoprotective effects of Ethanolic Extract of Oxalis stricta Linn.(EEOS) towards Paracetamol intoxicated hepatic damage in Albino rats. The various extracts were prepared dose form 250 mg/kg and 500mg/kg against liver toxicity induced by Paracetamolat a dose of 2 gm/kg p.o once daily. Serum glutamate pyruvate tranaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP) and bilirubin content which was elevated due to Paracetamol intoxication was significantly reduced by the extract. Standard drug Silymarin was used as reference. In Paracetamol alone treated animals shows lipid peroxidation was increased with decrease in superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) levels which represents the hepatic antioxidant status. It was further confirmed by histopathological observations. Futher Histopathological observations indicated. From the results it may be concluded that the 70% ethanolic extract of Oxalis stricta Linn. Possess hepatoprotective activity.