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      Vitamin D and autoimmunity: new aetiological and therapeutic considerations.

      Annals of the Rheumatic Diseases
      Aged, Anti-Inflammatory Agents, therapeutic use, Arthritis, Rheumatoid, drug therapy, immunology, Autoimmune Diseases, Diabetes Mellitus, Type 1, Humans, Hypersensitivity, etiology, Infant, Newborn, Inflammatory Bowel Diseases, Lymphocytes, Multiple Sclerosis, Vitamin D, adverse effects

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          Abstract

          Vitamin D is frequently prescribed by rheumatologists to prevent and treat osteoporosis. Several observations have shown that vitamin D inhibits proinflammatory processes by suppressing the enhanced activity of immune cells that take part in the autoimmune reaction. Moreover, recent evidence strongly suggests that vitamin D supplementation may be therapeutically beneficial, particularly for Th1-mediated autoimmune disorders. Some reports imply that vitamin D may even be preventive in certain disorders such as multiple sclerosis and diabetes type 1. It seems that vitamin D has crossed the boundaries of calcium metabolism and has become a significant factor in a number of physiological functions, specifically as a biological inhibitor of inflammatory hyperactivity.

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