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      Effects of Thyroid Hormone on mRNAs of Phosphoglycerate Mutase Subunits in Rat Muscle during Development

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          Background: We previously showed that triiodothyronine (T3) stimulates muscle phosphoglycerate mutase (PGAM) activity and isozyme transition in rat skeletal and cardiac muscles. Methods: The effects of T3 on PGAM types B and M subunit expression in rat muscle during development are reported. Results: T3 administration during the first 21 days of rat life more than doubles type M PGAM mRNA levels, but produces minor effects on type B PGAM mRNA levels. The antihormone propylthiouracil (PTU) slightly decreases both type B and M mRNA levels, but this decrease is not statistically significant. Conclusion: Thyroid hormone influences PGAM mRNA isozyme levels differently and increases type M mRNA.

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          Most cited references 6

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          Isolation and sequencing of a cDNA encoding the B isozyme of rat phosphoglycerate mutase

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            Expression of phosphoglycerate mutase mRNA in differentiating rat satellite cell cultures

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              Thyroid hormone stimulates phosphoglycerate mutase activity and isozyme transition in rat muscle tissues


                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                29 April 2002
                : 57
                : 1-2
                : 48-52
                Unitat de Bioquimica, Departament de Ciéncies Fisiològiques I, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina, Universitat de Barcelona, Spain
                57947 Horm Res 2002;57:48–52
                © 2002 S. Karger AG, Basel

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                Page count
                Figures: 2, Tables: 1, References: 39, Pages: 5
                Original Paper


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