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      SIRT1 and energy metabolism.

      1
      Acta biochimica et biophysica Sinica
      Oxford University Press (OUP)

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          Abstract

          Sirtuin 1 (SIRT1) is the most conserved mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. In response to different environmental stimuli, SIRT1 directly links the cellular metabolic status to the chromatin structure and the regulation of gene expression, thereby modulating a variety of cellular processes such as energy metabolism and stress response. Recent studies have shown that SIRT1 controls both glucose and lipid metabolism in the liver, promotes fat mobilization and stimulates brown remodeling of the white fat in white adipose tissue, controls insulin secretion in the pancreas, senses nutrient availability in the hypothalamus, influences obesity-induced inflammation in macrophages, and modulates the activity of circadian clock in metabolic tissues. This review focuses on the role of SIRT1 in regulating energy metabolism at different metabolic tissues.

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          Author and article information

          Journal
          Acta Biochim Biophys Sin (Shanghai)
          Acta biochimica et biophysica Sinica
          Oxford University Press (OUP)
          1745-7270
          1672-9145
          Jan 2013
          : 45
          : 1
          Affiliations
          [1 ] Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Lix3@niehs.nih.gov
          Article
          gms108
          10.1093/abbs/gms108
          3527007
          23257294
          bc3bc625-ef0c-441b-95d4-b4f50eb5c005
          History

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