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Subinhibitory concentrations of antibiotics induce phenazine production in a marine Streptomyces sp.

Journal of Natural Products

analysis, pharmacology, Bacillus subtilis, drug effects, Candida glabrata, Marine Biology, Microbial Sensitivity Tests, chemistry, Phenazines, isolation & purification, metabolism, Staphylococcus, Streptomyces, Anti-Bacterial Agents

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      Subinhibitory concentrations of antibiotics were found to enhance and modulate the production of new phenazines, streptophenazines A-H, in a marine Streptomyces isolate. The streptophenazines differ in length and substitution of an alkyl chain. The pattern of metabolites formed depends on the antibiotic used. In the presence of tetracycline, streptophenazines F and G were induced and the production of streptophenazines A-D was increased. When using bacitracin, mainly streptophenazine H was produced. Streptophenazines C and H showed moderate activity against Bacillus subtilis, while streptophenazine C was also active against Staphylococcus lentus.

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