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      Exaggerated Natriuresis in the Course of Poststreptococcal Glomerulonephritis

      , ,

      Nephron

      S. Karger AG

      Poststreptococcal glomerulonephritis, Exaggerated natriuresis

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          Abstract

          The response to rapid infusion of 2.5% saline solution was examined in 21 patients 1–15 years after an episode of acute poststreptococcal glomerulonephritis. 12 were normotensive and 9 hypertensive; 11 had minimal proteinuria; renal biopsies showed varying degrees of glomerular sclerosis in 9 and were normal in the remainder; filtration rates ranged from 151 to 26 ml/min. Exaggerated natriuresis during the saline load occurred in 19 of the 21. The occurrence or magnitude of natriuresis was not dependent on the level of filtration rate or the presence of hypertension. The renal mechanism, which could not be attributed to increase in filtration rate, decrease in peritubular oncotic pressure, or increase in intrarenal pressure, is unexplained. It is suggested that this remarkably altered reactivity to saline loading reflects the presence of diseased nephrons and constitutes further evidence that irreversible renal damage occurs commonly following acute poststreptococcal glomerulonephritis.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1974
          1974
          28 November 2008
          : 13
          : 5
          : 349-364
          Affiliations
          Hypertension and Renal Disease Section, Departments of Medicine and Pediatrics, New York University School of Medicine, New York, N.Y.
          Article
          180411 Nephron 1974;13:349–364
          10.1159/000180411
          4431546
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 16
          Categories
          Paper

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