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      Studies of Circulating Immune Complexes and Lymphocyte Subpopulations in Childhood IgM Mesangial Nephropathy

      a , b

      Nephron

      S. Karger AG

      Circulating immune complexes, OKT8 cell, IgM mesangial nephropathy

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          Abstract

          T cell subsets, serum immunoglobulin (IgM) level, IgM-bearing lymphocytes, and circulating immune complexes (CIC) were studied in 12 children who suffered from IgM mesangial nephropathy (IgMN) during the acute nephrotic phase, in remission and relapse. Frequent relapses were observed in 11 cases, and 1 was partially responsive to steroid treatment. IgMN was diagnosed by the consistent pattern of IgM deposition by all four FITC-labelled antihuman IgM antibodies from rabbits and goats supplied by four different companies and by the 100% positivity of electron-dense mesangial deposits in an identical localization and distribution pattern of kidney biopsy specimen. CIC were detected by the 3.5% polyethylene glycol method. In sera from 12 patients IgM CIC were detected in 8 cases during the acute nephrotic phase. High levels of C3 CIC and C4 CIC were also found in these cases during the acute nephrotic phase. The CIC were undetectable in remission. Only 3 cases were detectable at low levels of IgM CIC during the second relapse. High serum IgM levels and IgM-bearing lymphocytes were noted in these patients. The patients also had a significant increase of OKT8 cells and a decrease in the OKT4/OKT8 ratio during the acute phase and in relapse. Taken together, the immunopathologic and clinical features suggest that IgMN is a disease entity with a chiefly classical pathway activation of complement components. The correlation between the changes of T cell subsets and the disease activity in IgMN suggests that this may serve as a therapeutic and prognostic guide.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1986
          1986
          05 December 2008
          : 44
          : 3
          : 198-203
          Affiliations
          aPediatric Research Laboratory, Department of Medical Research and Pediatrics, Veterans General Hospital Taiwan, Taipei, Republic of China; bDepartment of Pediatrics, Osaka University School of Medicine, Osaka, Japan
          Article
          183986 Nephron 1986;44:198–203
          10.1159/000183986
          3491333
          © 1986 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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