- Record: found
- Abstract: not found
- Article: not found
Revised methods for the Salmonella mutagenicity test
March 1983
March 1983
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
<p class="first" id="d9142050e49">The methods for detecting carcinogens and mutagens
with the Salmonella mutagenicity
test were described previously (Ames et al., 1975b). The present paper is a revision
of the methods. Two new tester strains, a frameshift strain (TA97) and a strain carrying
an ochre mutation on a multicopy plasmid (TA102), are added to the standard tester
set. TA97 replaces TA1537. TA1535 and TA1538 are removed from the recommended set
but can be retained at the option of the investigator. TA98 and TA100 are retained.
We discuss other special purpose strains and present some minor changes in procedure,
principally in the growth, storage, and preservation of the tester strains. Two substitutions
are made in diagnostic mutagens to eliminate MNNG and 9-aminoacridine. Some test modifications
are discussed.
</p>