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      Anticlastogenic effect of caffeic acid phenethyl ester on cisplatin-induced chromosome aberrations in rat bone marrow cells.

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          Abstract

          Caffeic acid phenethyl ester (CAPE) is an antioxidant that can scavenge free radicals and protect cellular macromolecules, including DNA and proteins, from oxidative damage induced by various agents. The protective effect of CAPE on cisplatin-induced chromosome aberrations has been determined in rat bone marrow cells. The animals were pretreated with a single dose of CAPE (10 micromol/kg body weight [b.w.]) injected intraperitoneally (i.p.) 24 hours before the administration of cisplatin and then sacrificed 24 hours after the cisplatin administration. Cisplatin was administered to rats either alone (5 mg/kg b.w., i.p.) or after CAPE treatment. CAPE has led to a statistically significant decrease in the total number of chromosomal aberrations and abnormal metaphases induced by cisplatin when compared with only cisplatin given groups. We have concluded that CAPE could prevent cisplatin-induced chromosome aberrations by establishing a potent free radical scavenger effect.

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          Author and article information

          Journal
          Toxicol Ind Health
          Toxicology and industrial health
          SAGE Publications
          1477-0393
          0748-2337
          Feb 2010
          : 26
          : 1
          Affiliations
          [1 ] Department of Medical Biology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey. hramazany@yahoo.com
          Article
          0748233709355731
          10.1177/0748233709355731
          19933724
          bca3f1e2-0d98-4f8a-a79a-f675e3b96097
          History

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